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Vascular biology associated with metabolic disorders. Current work examines the interaction of insulin- like growth factor (IGF-1) and angiotensin II (AngII) / Estradiol (E2) in regulation of gene expression/ activity of the nitric oxide synthase enzymes and of hyperglycemia, insulin/IGF-1 resistant states and under conditions where AngII is overexpressed in cardiovascular tissue. Work supported by the NIH, VA Merit and ADA also examines the role of estradiol and gender in mediating the interactive signalling of Ang II and IGF-1 in cardiomyocytes, vascular smooth muscle cells and endothelial cells. Molecular techniques include adenovirus transfection and knockout of various intermediate pathways such as the PI3-kinase pathway.
Funded by multiple grants from the National Institute of Health and the Veterans Administration.
CURRENT GRANT SUPPORT
2000-2003 ADA, Vascular Interactions of Estradiol and Insulin-Like Growth Factor.
SELECTED RECENT PUBLICATIONS
1. Ali SS, Igwe RC, Walsh MF, Sowers JR. Troglitazone and vascular reactivity: role of glucose and calcium. Metabolism 1999;48(1):125-130.
2. Ren J, Sowers JR, Natavio M, Brown RA. Influence of age on inotropic response to insulin and insulin-like growth factor 1 in spontaneously hypertensive rats: role of nitric oxide. PSEBM 1999;221:46-52. Sowers JR, Draznin B. Insulin, cation metabolism and insulin resistance. J Basic & Clin Physiol & Pharmacol 1999;9(2-4):223-233.
3. Ren J, Walsh MF, Hamaty M, Sowers JR, Brown RA. Augmentation of the inotropic response to insulin in diabetic rat hearts. Life Sciences 65(4):369-380, 1999.
4. Grundy SM, Benjamin IJ, Burke GL, Chair A, Eckel RH, Howard BV, Mitch W, Smith SC, Sowers JR. Diabetes and cardiovascular disease. A statement for healthcare professionals from the American Heart Association Circulation 100:1134-1146, 1999.
5. Ren J, Dominguez LJ, Sowers JR, Davidoff AJ. Metformin but not glyburide prevents high glucose- induced abnormalities in relaxation and intracellular Ca2+ transients in adult rat ventricular myocytes. Diabetes 48:2059-2065, 1999.
6. Jacober SJ, Sowers JR. An update on perioperative management of diabetes Arch Intern Med 159:2405- 2411, 1999.
7. Ren J, Samson WK, Sowers JR. Insulin-like growth factor 1 as a cardiac hormone: physiological and pathophysiological implications in heart disease. J Mol Cell Cardiol 31:2049-2061, 1999.
8. Ren J, Jefferson L, Sowers JR, Brown RA. Influence of age on contractile response to insulin-like growth factor 1 in ventricular myocytes from spontaneously hypertensive rats. Hypertension 34:1215-1222, 1999.
9. Hamaty M, Guzman CB, Walsh MF, Bode AM, Levy J, Sowers JR. High glucose-enhanced acetylcholine stimulated cGMP masks impaired vascular reactivity in tail arteries from short-term hyperglycemic rats. Int Jnl Experimental Diab Res 1:69-79, 2000.
10. Sowers JR, Lester M. Hypertension, hormones and aging. J Lab Clin Med 135::379-386, 2000.
11. Bakris GL, Williams M, Dworkin L, Elliott WJ, Epstein M, Toto R, Tuttle K, Douglas J, Hsueh W, Sowers JR for the National Kidney Foundation Hypertension and Diabetes Executive Committees Working Group. Preserving renal function in adults with hypertension and diabetes: A consensus Approach. Am J Kidney Dis 36(3):645--661, 2000.
12. Sowers JR. Common pathophysiological issues in diabetes and cardiovascular disease. Cardiol Rev 17(4):13-23, 2000.
13. Muniyappa R, Xu R, Ram JL, Sowers JR. Inhibition of Rho protein stimulates iNOS expression in rat vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 278;H1762-H1768, 2000
14. McFarlane SI, Banerji M, Sowers JR. Insulin resistance and cardiovascular disease. J Clin Endocrinol Metab 86(2):713-718, 2001.
15. Muniyappa R, Srinivas PR, Ram JL, Sowers JR. Glucose-induced inhibition of inducible nitric oxide synthase in vascular smooth muscle cells - role of protein kinase C betaII and Rho. J Diabetes Complications 15 (1):22, 2001.
16. Sowers JR. Hyperglycemia-related alterations in vascular nitric oxide production. J Diabetes Complications. 15(1):6, 2001.
17. Guzman CB, Walsh M, Reddy V, Donthireddy V, Mahmood F, Bode A, Turner
18. JR, Jacober SJ, Sowers JR. Altered myosin light-chain phosphorylation in resting platelets from premenopausal women with diabetes. Metabolism 50(2):151-156, 2001.
19. Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: An update. Hypertension 37:1053-1059, 2001.
20. Walsh MF, Ali SS, Sowers JR. Vascular insulin/insulin-like growth factor-1 resistance in female obese Zucker rats. Metabolism 50(5):607-612, 2001.
21. Winer N, Sowers JR, Weber MA. Gender differences in vascular compliance in young, healthy subjects assessed by pulse contour analysis. J Clin Hypertens 3:145-152, 2001.
JAMES RUSSELL SOWERS, MD, FACP
Professor of Medicine and Cell Biology
Telephone: 270 4528
Fax: 270 1699
Email: jsowers@netmail.hscbklyn.edu
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